Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716728 | 0.92 | SYK (0.56) | SYKCA1CA2CA9CDK2 | |
| SCHEMBL2717957 | 0.88 | SYK (0.57) | SYKCA1CA2CA9CDK2 | |
| SCHEMBL10272182 | 0.81 | CA1 (0.47) | SYKCA1CA2CA9CDK2 | |
| SCHEMBL2716069 | 0.81 | SYK (0.56) | SYKGSK3B | |
| SCHEMBL2719063 | 0.80 | SYK (0.58) | SYKKDM4E | |
| SCHEMBL10128227 | 0.78 | SYK (0.67) | SYK | |
| SCHEMBL10128611 | 0.78 | EML4 (0.61) | SYKCDK2 | |
| SCHEMBL10128661 | 0.73 | SYK (0.47) | SYK | |
| SCHEMBL10272212 | 0.73 | CA1 (0.51) | CA1CA2CA9CDK2CCNA2 | |
| SCHEMBL2715816 | 0.72 | SYK (0.58) | SYKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |