Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054899 | 1.00 | TRPV1 (0.35) | TRPV1EDNRAPKMKDM4EMAPT | |
| SCHEMBL1029637 | 1.00 | TRPV1 (0.35) | TRPV1EDNRAPKMKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL4248076 | 0.99 | TRPV1 (0.35) | TRPV1EDNRAPKMKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL4252555 | 0.99 | TRPV1 (0.35) | TRPV1EDNRAPKMKDM4EMAPT | |
| SCHEMBL1033623 | 0.91 | CYP2C19 (0.39) | TRPV1PKMMAPTCYP2C19SQSTM1 | |
| Hydrochloric Acid SCHEMBL4245236 | 0.90 | CYP2C19 (0.38) | TRPV1PKMMAPTCYP2C19SQSTM1 | |
| SCHEMBL1028955 | 0.89 | TRPV1 (0.35) | TRPV1EDNRAPKMKDM4EMAPT | |
| SCHEMBL1031769 | 0.89 | TRPV1 (0.36) | TRPV1EDNRA | |
| SCHEMBL4045301 | 0.89 | LMNA (0.35) | TRPV1EDNRACYP2C19MEN1KMT2A | |
| SCHEMBL1032277 | 0.89 | LMNA (0.35) | TRPV1EDNRACYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013179-B1 | ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-01-19 | — | — | EP | disclosed |
| EP-2013179-A1 | ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007118859-A1 | ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2007-10-25 | — | — | WO | disclosed |