Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 7/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747669 | 0.95 | CSNK1D (0.39) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL5955411 | 0.90 | GSK3B (0.41) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL253785 | 0.89 | GSK3B (0.47) | CSNK1DCSNK1EKDRWNT1GSK3B | |
| SCHEMBL2745972 | 0.88 | CDK9 (0.36) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL2745977 | 0.88 | CDK9 (0.36) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL2746459 | 0.88 | CDK9 (0.36) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL5955085 | 0.87 | CCNC (0.39) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL5955082 | 0.87 | CDK9 (0.39) | CSNK1DCSNK1ECDK9KDRWNT1 | |
| SCHEMBL5955181 | 0.85 | KDR (0.39) | PIK3CACSNK1DCSNK1ECDK9KDR | |
| SCHEMBL2746330 | 0.84 | CSNK1D (0.45) | CSNK1DCSNK1ECDK9KDRRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |