Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 6/20 | 0.44 |
| ▸ | AKT2 | P31751 | 6/20 | 0.44 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275636 | 0.90 | ADORA1 (0.43) | MAPTTP53THRBADORA2AADORA1 | |
| SCHEMBL10313596 | 0.83 | KDM4E (0.47) | MAPTTP53ADORA2AADORA1KMT2A | |
| SCHEMBL10276001 | 0.78 | AR (0.38) | MAPTTP53THRBADORA2AADORA1 | |
| SCHEMBL10275338 | 0.76 | AR (0.43) | MAPTTP53THRBKMT2AMEN1 | |
| SCHEMBL10275813 | 0.76 | AR (0.42) | MAPTTP53KDM4EALDH1A1HPGD | |
| SCHEMBL10313497 | 0.75 | KDM4E (0.49) | MAPTTP53ADORA2AADORA1KMT2A | |
| SCHEMBL10275992 | 0.75 | TP53 (0.44) | MAPTTP53THRBKMT2AMEN1 | |
| SCHEMBL10276046 | 0.73 | AR (0.41) | MAPTADORA2AADORA1KMT2AMEN1 | |
| SCHEMBL10276212 | 0.73 | SLC22A12 (0.43) | MAPTTP53KMT2AMEN1KDM4E | |
| SCHEMBL12826358 | 0.69 | KDM4E (0.47) | MAPTTP53THRBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | MAPT 750/4885TP53 2161/4885THRB 1178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.