Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954190 | 1.00 | PPM1B (0.44) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL3954185 | 1.00 | PPM1B (0.44) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL6406115 | 0.85 | PPM1B (0.41) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL32677646 | 0.83 | PPM1B (0.46) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL12994228 | 0.82 | ALDH1A1 (0.53) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL19032664 | 0.76 | CYP4F2 (0.43) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL34472423 | 0.75 | CYP2C19 (0.40) | PPM1BPTPN1PPP1CCALDH1A1HSD17B10 | |
| SCHEMBL19874145 | 0.75 | PPM1B (0.47) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL24318061 | 0.73 | KDM4E (0.51) | PPM1BPTPN1PPP1CCALDH1A1LMNA | |
| SCHEMBL13449461 | 0.73 | PPM1B (0.60) | PPM1BPTPN1PPP1CCALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814855-B1 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-19 | — | — | EP | disclosed |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | BOEHRINGER MARKUS | 2009-10-29 | — | — | US | disclosed |
| US-7501413-B2 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1814855-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-08-08 | — | — | EP | disclosed |
| US-7081481-B2 | Excitatory amino acid receptor modulators | ELI LILLY AND COMPANY (US) | 2006-07-25 | — | — | US | disclosed |
| US-20060106016-A1 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-05-18 | — | — | US | disclosed |
| WO-2006048152-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |
| EP-1189874-B1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | LILLY SA (ES) | 2005-01-26 | — | — | EP | disclosed |
| US-20040102521-A1 | Excitatory amino acid receptor modulators | ELI LILLY AND COMPANY | 2004-05-27 | — | — | US | disclosed |
| EP-1289935-A1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6504052-B1 | 2-carboxycyclopropyl glycine derivatives, used as agonists of glutamate receptors for prophylaxis of psychological and nervous system disorders; anxiolytics; antidepressants; drug abuse; anticonvulsant, analgesic and antiemetic agents | ELI LILLY AND COMPANY | 2003-01-07 | — | — | US | disclosed |
| US-6498180-B1 | SUCH AS 2-(3'-HYDROXYMETHYL-2'-CARBOXYCYCLOPROPYL)GLYCINE; MODULATING METABOTROPIC GLUTAMATE RECEPTOR; TREATING DISORDERS OF CENTRAL NERVOUS | ELI LILLY AND COMPANY | 2002-12-24 | — | — | US | disclosed |
| WO-2001092212-A1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106016-A1 | Dicarboxamide derivatives | F2, F12, TFPI | PPM1B 3729/4885PTPN1 3586/4885PPP1CC 4310/4885 |
| US-20040102521-A1 | Excitatory amino acid receptor modulators | GRM1, GRM2, GRIN1 | PPM1B 2017/4885PTPN1 1155/4885PPP1CC 3447/4885 |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | F2, F12, TFPI | PPM1B 3729/4885PTPN1 3586/4885PPP1CC 4310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.