Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 7/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL10277408 | 0.89 | PARP1 (0.59) | PARP1TSHRPOLBCYP3A4MAPT | |
| Trifluoroacetic Acid SCHEMBL29713373 | 0.89 | PARP1 (0.59) | PARP1TSHRPOLBCYP3A4MAPT | |
| 3-Aminobenzamide SCHEMBL16070 | 0.87 | PBRM1 (0.63) | PBRM1PARP1F2PLGPRSS1 | |
| 3-Aminobenzamide SCHEMBL27679552 | 0.87 | PBRM1 (0.63) | PBRM1PARP1F2PLGPRSS1 | |
| 3-Aminobenzamide SCHEMBL28015741 | 0.85 | PBRM1 (0.61) | PBRM1PARP1F2PLGPRSS1 | |
| 3-Aminobenzamide SCHEMBL8688920 | 0.85 | F2 (0.63) | PBRM1PARP1F2PLGPRSS1 | |
| 3-Aminobenzamide SCHEMBL28944114 | 0.85 | PBRM1 (0.61) | PBRM1PARP1F2PLGPRSS1 | |
| Terephthalic Acid SCHEMBL28053568 | 0.81 | PBRM1 (0.58) | PBRM1PARP1F2PLGPRSS1 | |
| Trifluoroacetic Acid SCHEMBL7759604 | 0.81 | DHODH (0.58) | PARP1PRSS1PRSS2PRSS3TSHR | |
| Trifluoroacetic Acid SCHEMBL30687977 | 0.81 | DHODH (0.58) | PARP1PRSS1PRSS2PRSS3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590942-B1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-05-04 | — | — | EP | disclosed |
| US-9079880-B2 | Rho kinase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| EP-2590942-A1 | RHO KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-20120178752-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-12 | — | — | US | disclosed |
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178752-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | PBRM1 2888/4885PARP1 1130/4885PTGS1 407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.