Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 5/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | NMT2 | O60551 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15450622 | 0.90 | GPR6 (0.30) | GPR6 | |
| SCHEMBL10356289 | 0.88 | — | — | |
| SCHEMBL361518 | 0.87 | EGFR (0.33) | RAB9AMEN1KMT2A | |
| SCHEMBL10279996 | 0.83 | MAOB (0.32) | KDM4EMEN1KMT2AMAOB | |
| SCHEMBL10356082 | 0.83 | KDM4E (0.39) | KDM4EBCHEACHENPC1RAB9A | |
| SCHEMBL10357076 | 0.81 | PSEN1 (0.43) | CYP3A4CYP2D6 | |
| SCHEMBL10356097 | 0.81 | GPR6 (0.32) | CYP3A4CYP2D6GPR6 | |
| SCHEMBL10353158 | 0.80 | — | — | |
| SCHEMBL10353095 | 0.77 | S1PR4 (0.31) | RAB9AMEN1KMT2A | |
| SCHEMBL10353230 | 0.76 | PSEN1 (0.43) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009309-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-19 | — | — | WO | disclosed |