SCHEMBL10279831

SCHEMBL10279831

C=C(N[C@@H](C)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1cccc(OC)c1)C(F)(F)F

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.83
PGR P06401 3/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azd-5423 SCHEMBL22265154 0.91 NR3C1 (1.00) NR3C1PGR
Azd-5423 SCHEMBL15780379 0.91 NR3C1 (1.00) NR3C1PGR
Azd-5423 SCHEMBL29373225 0.91 NR3C1 (1.00) NR3C1PGR
Azd-5423 SCHEMBL29968143 0.91 NR3C1 (1.00) NR3C1PGR
Azd-5423 SCHEMBL524608 0.91 NR3C1 (1.00) NR3C1PGR
Azd-5423 SCHEMBL524607 0.91 NR3C1 (1.00) NR3C1PGR
SCHEMBL835838 0.89 NR3C1 (0.82) NR3C1PGR
SCHEMBL836577 0.89 NR3C1 (0.82) NR3C1PGR
SCHEMBL835839 0.89 NR3C1 (0.82) NR3C1PGR
SCHEMBL836578 0.89 NR3C1 (0.82) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102169-B1 INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS ASTRAZENECA AB (SE) 2012-06-20 EP disclosed