Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336117 | 0.86 | JAK3 (0.51) | ALKBRD4JAK3MAPK9MAPK10 | |
| SCHEMBL13623215 | 0.85 | JAK3 (0.48) | ALKBRD4JAK3MAPK9MAPK10 | |
| SCHEMBL4357327 | 0.83 | EGFR (0.39) | ALKJAK3EGFRBCL6BTK | |
| SCHEMBL1025607 | 0.81 | STK17B (0.39) | EGFRBCL6BTK | |
| SCHEMBL1082585 | 0.81 | MAPK9 (0.46) | ALKJAK3MAPK9MAPK10PKMYT1 | |
| SCHEMBL1025252 | 0.79 | ALDH1A1 (0.39) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4352505 | 0.79 | MAPK9 (0.45) | ALKBRD4JAK3MAPK9MAPK10 | |
| SCHEMBL13669691 | 0.77 | MAPK9 (0.44) | ALKBRD4JAK3MAPK9MAPK10 | |
| SCHEMBL13622525 | 0.77 | MAPK9 (0.42) | ALKBRD4JAK3MAPK9MAPK10 | |
| SCHEMBL13623218 | 0.77 | JAK3 (0.51) | BRD4JAK3EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |