Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880251 | 0.87 | LMNA (0.61) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880385 | 0.81 | LMNA (0.65) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880307 | 0.77 | IDO1 (0.70) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880369 | 0.76 | LMNA (0.59) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880243 | 0.76 | LMNA (0.59) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880257 | 0.76 | LMNA (0.59) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL852442 | 0.76 | LMNA (0.72) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880224 | 0.75 | TP53 (0.62) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880435 | 0.75 | MAPT (0.68) | LMNAHSD17B10MAPTSMN1; SMN2HTT | |
| SCHEMBL880496 | 0.75 | LMNA (0.61) | LMNAHSD17B10MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |