Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 8/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281619 | 0.89 | PARP1 (0.52) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL6128542 | 0.89 | KDM4E (0.48) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL706999 | 0.89 | KDM4E (0.48) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10281290 | 0.87 | KMT2A (0.51) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10281200 | 0.86 | KMT2A (0.50) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10281160 | 0.86 | KMT2A (0.49) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10281201 | 0.85 | KMT2A (0.48) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL710316 | 0.84 | KMT2A (0.53) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL10281542 | 0.84 | PARP1 (0.52) | KMT2AKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL708269 | 0.84 | ALDH1A1 (0.55) | KMT2AKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124606-B2 | Substituted 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-ones | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20110158989-A1 | Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110158989-A1 | Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS | PARP1, PARP3, PARP2 | KMT2A 1299/4885KDM4E 1974/4885ALDH1A1 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.