Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 7/20 | 0.39 |
| ▸ | TRIM58 | Q8NG06 | 3/20 | 0.38 |
| ▸ | RAD52 | P43351 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528829 | 0.78 | MELK (0.40) | MELKTRIM58RAD52POLBNPC1 | |
| SCHEMBL15190679 | 0.77 | TERT (0.43) | MELKTRIM58RAD52POLBNPC1 | |
| SCHEMBL10282421 | 0.75 | MELK (0.48) | MELKTRIM58 | |
| SCHEMBL17450160 | 0.74 | MELK (0.60) | MELK | |
| SCHEMBL529115 | 0.74 | MELK (0.51) | MELKTRIM58KMT2AMAPK1 | |
| SCHEMBL530333 | 0.73 | MELK (0.52) | MELKKMT2A | |
| SCHEMBL528976 | 0.73 | MELK (0.39) | MELKTRIM58RAD52POLBNPC1 | |
| SCHEMBL529565 | 0.71 | MELK (0.48) | MELKRAD52POLBKMT2ACYP1A2 | |
| SCHEMBL15190668 | 0.70 | KMT2A (0.66) | RAD52POLBKMT2ACYP1A2ALDH1A1 | |
| SCHEMBL528977 | 0.70 | MELK (0.47) | MELKRAD52POLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |