TERT — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL35318	1.00	14/20
SCHEMBL20869	1.00	9/20
SCHEMBL19721	0.86	9/20
SCHEMBL20107	0.73	9/20
SCHEMBL20252	0.73	9/20
SCHEMBL20173	0.64	9/20
SCHEMBL19727	1.00	8/20
SCHEMBL21536	0.66	8/20
SCHEMBL92104	0.54	8/20
SCHEMBL20399	0.49	8/20
Celastrol (SCHEMBL14954)	0.82	7/20
SCHEMBL19918	0.80	7/20
SCHEMBL20433	0.72	6/20
SCHEMBL19570	0.72	6/20
SCHEMBL20479	0.67	6/20
SCHEMBL20028	0.66	6/20
Tingenone (SCHEMBL17064)	0.63	6/20
Pristimerin (SCHEMBL15020)	0.84	5/20
SCHEMBL20780	0.71	5/20
SCHEMBL20022	0.68	5/20

Clinical trials — most relevant to TERT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma	PHASE2/PHASE3	COMPLETED
Low-Dose Danazol for the Treatment of Telomere Related Diseases	PHASE2	COMPLETED
Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors	PHASE2	WITHDRAWN
Human Telomerase Reverse Transcriptase Messenger RNA (hTERT mRNA) Transfected Dendritic Cell Vaccines	PHASE1/PHASE2	WITHDRAWN
Danazol for Genetic Bone Marrow and Lung Disorders	PHASE1/PHASE2	COMPLETED
Nandrolone Decanoate in the Treatment of Telomeropathies	PHASE1/PHASE2	COMPLETED
Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma	PHASE1	WITHDRAWN
INVAC-1 Anti-Cancer hTERT DNA Immunotherapy	PHASE1	COMPLETED
Safety and Dose Study of GRN163L Administered to Treat Patients With Refractory or Relapsed Multiple Myeloma	PHASE1	COMPLETED
CCRT With Temozolomide Versus RT Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas	EARLY_PHASE1	UNKNOWN
Multi-peptide Vaccine With Basilixumab for Breast Cancer	EARLY_PHASE1	COMPLETED
Impact of Diet and Physical Activity Changes on Body Weight, Biomarkers and Quality of Life in Breast Cancer Survivors	nan	COMPLETED
Anti-age Dietary Supplements in Healthy Older Adults: the proBNPage Reduction Trial	nan	UNKNOWN
Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder	nan	UNKNOWN
Telomere and Telomerase	nan	WITHDRAWN
Telomerase Activator and Retinal Amyloid	nan	COMPLETED
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals	nan	UNKNOWN
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients	nan	UNKNOWN
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Stress Management and Biological Age in Breast Cancer Patients.RCT	nan	COMPLETED
Vitamin D Supplementation on Surrogate Markers of Ageing, Ageing Genes, Glycemic and Metabolic Markers in North India	nan	UNKNOWN
Body Awareness and Aerobic Exercise: Telomere Impact	nan	COMPLETED
Telomerase Activity as a Marker For Mobilization Quality	nan	UNKNOWN
The Psychobiological Effects of Participation in a One-Month Insight Meditation Retreat	nan	COMPLETED
Chromosomal Translocations in Chandigarh Police	nan	COMPLETED
Calorie Restriction Retards the Aging Process	nan	UNKNOWN
Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients	nan	COMPLETED
Studying Biomarkers in Samples From Patients With High-Risk Neuroblastoma	nan	COMPLETED
Effects of TA-65, a Telomerase Activator on Metabolic Syndrome	nan	COMPLETED
Self-Directed Biological Transformation Initiative	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TERT binder may also engage these)

Protein	Name	Similarity
Q27ID4	—	1.000	Q27ID4 →
Q6A548	—	1.000	Q6A548 →
Q673L6	—	0.995	Q673L6 →
O70372	—	0.991	O70372 →
Q1PS67	—	0.985	Q1PS67 →
Q9H6W3	—	0.976	Q9H6W3 →
Q99MQ3	—	0.975	Q99MQ3 →
POLRMT	DNA-directed RNA polymerase, mitochondrial	0.975	landscape →
Q9H211	—	0.973	Q9H211 →
B5DFG1	—	0.973	B5DFG1 →
A0JN53	—	0.973	A0JN53 →
Q5ZMM1	—	0.973	Q5ZMM1 →
Q400G9	—	0.973	Q400G9 →
Q76KP1	—	0.973	Q76KP1 →
O75064	—	0.973	O75064 →
Q86UT6	—	0.972	Q86UT6 →
Q29RR1	—	0.972	Q29RR1 →
Q8BH02	—	0.972	Q8BH02 →
Q562E7	—	0.972	Q562E7 →
PINK1	Serine/threonine-protein kinase PINK1, mitochondrial	0.972	landscape →
Q3T1I9	—	0.972	Q3T1I9 →
Q9NXH8	—	0.972	Q9NXH8 →
Q400C9	—	0.972	Q400C9 →
Q9JL70	—	0.972	Q9JL70 →
Q15345	—	0.972	Q15345 →
TELO2	Telomere length regulation protein TEL2 homolog	0.971	landscape →
Q2KHV9	—	0.971	Q2KHV9 →
CCDC22	Coiled-coil domain-containing protein 22	0.971	landscape →
G3X992	—	0.971	G3X992 →
Q8WVB6	—	0.971	Q8WVB6 →