Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281522 | 0.87 | JAK1 (0.56) | JAK1JAK2JAK3 | |
| SCHEMBL9953870 | 0.87 | JAK1 (0.73) | JAK1JAK2 | |
| SCHEMBL10281513 | 0.84 | JAK1 (0.70) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281994 | 0.84 | JAK1 (0.61) | JAK1JAK2 | |
| SCHEMBL9953424 | 0.84 | JAK1 (0.72) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281983 | 0.83 | JAK1 (0.60) | JAK1JAK2 | |
| SCHEMBL9953151 | 0.83 | JAK2 (0.70) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281980 | 0.82 | JAK1 (0.57) | JAK1JAK2 | |
| SCHEMBL12518783 | 0.82 | JAK1 (0.62) | JAK1JAK2 | |
| SCHEMBL10281500 | 0.82 | JAK1 (0.55) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |