Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.72 |
| ▸ | JAK2 | O60674 | 14/20 | 0.72 |
| ▸ | TYK2 | P29597 | 10/20 | 0.70 |
| ▸ | JAK3 | P52333 | 10/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281519 | 0.91 | JAK1 (0.60) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281488 | 0.89 | JAK2 (0.72) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281984 | 0.86 | JAK1 (0.57) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2225210 | 0.84 | JAK2 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281979 | 0.84 | JAK1 (0.55) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL10281513 | 0.83 | JAK1 (0.70) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12384934 | 0.82 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2274296 | 0.82 | JAK1 (0.76) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385332 | 0.82 | JAK1 (0.76) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385315 | 0.82 | JAK1 (0.75) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085176-A1 | TRICYCLIC PYRAZINONE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF AS JANUS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-28 | — | — | WO | disclosed |