Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89822 | 0.95 | REN (0.44) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL1911409 | 0.95 | REN (0.44) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90670 | 0.93 | REN (0.43) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90182 | 0.93 | REN (0.43) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL89798 | 0.92 | REN (0.42) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90131 | 0.92 | REN (0.43) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL89938 | 0.91 | REN (0.41) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90585 | 0.91 | REN (0.41) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90110 | 0.91 | REN (0.48) | RENKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL90061 | 0.91 | REN (0.46) | RENKMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |