Sugi Predict

Sugi Predict / Targets / REN

REN

Renin · P00797 · REN on Sugi Atlas →

122,526 patent compounds predicted against REN, 61,089 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL88887 SCHEMBL88887 1.00 20/20
SCHEMBL89535 SCHEMBL89535 1.00 20/20
SCHEMBL89553 SCHEMBL89553 1.00 20/20
SCHEMBL89625 SCHEMBL89625 1.00 20/20
SCHEMBL89850 SCHEMBL89850 1.00 20/20
SCHEMBL89968 SCHEMBL89968 1.00 20/20
SCHEMBL90128 SCHEMBL90128 1.00 20/20
SCHEMBL90342 SCHEMBL90342 1.00 20/20
SCHEMBL90442 SCHEMBL90442 0.93 20/20
SCHEMBL89402 SCHEMBL89402 0.90 20/20
SCHEMBL90565 SCHEMBL90565 0.88 20/20
SCHEMBL90047 SCHEMBL90047 0.87 20/20
SCHEMBL90322 SCHEMBL90322 0.87 20/20
SCHEMBL90699 SCHEMBL90699 0.86 20/20
SCHEMBL88964 SCHEMBL88964 0.83 20/20
SCHEMBL90433 SCHEMBL90433 0.83 20/20
SCHEMBL90457 SCHEMBL90457 0.82 20/20
SCHEMBL90315 SCHEMBL90315 0.81 20/20
SCHEMBL88982 SCHEMBL88982 0.80 20/20
SCHEMBL89781 SCHEMBL89781 0.80 20/20

Clinical trials — most relevant to REN by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Role of Vitamin K2 in Chronic Kidney Disease PHASE4RECRUITING
Role of Coenzyme Q10 in Chronic Kidney Disease PHASE4RECRUITING
Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension PHASE4COMPLETED
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE) PHASE4UNKNOWN
Effects of Aliskiren in Elderly Hypertensive Chronic Kidney Disease (CKD) Patients PHASE4COMPLETED
ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases PHASE4RECRUITING
Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects PHASE4COMPLETED
The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on Proteinuria PHASE4COMPLETED
Efficacy and Safety of Azilsartan Medoxomil in African American Participants With Essential Hypertension PHASE3COMPLETED
Effects of Linagliptin on Renal Endothelium Function in Patients With Type 2 Diabetes. PHASE3COMPLETED
Efficacy and Safety of Paricalcitol for Reduction of Proteinuria in Kidney Transplant Recipients PHASE3COMPLETED
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients PHASE3COMPLETED
Eplerenone, ACE Inhibition and Albuminuria PHASE2COMPLETED
Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination PHASE2UNKNOWN
Expression and Function of the Renin-Angiotensin System in the Esophagus EARLY_PHASE1COMPLETED
Renin as a Biomarker of Haemodynamic Normalisation nanCOMPLETED
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker nanUNKNOWN
Spironolactone for Reducing Proteinuria in Diabetic Nephropathy nanCOMPLETED
Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK) nanCOMPLETED
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System nanCOMPLETED
Optimalization of Nephroprotection Using N-Acetylcysteine nanCOMPLETED
Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure nanCOMPLETED
Optimalization of Nephroprotection Using Atorvastatin (Sortis) nanCOMPLETED
Long-term of Remote Ischemic Preconditioning and Mindfulness in Patients With Mild Hypertension nanRECRUITING
Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Risk of COVID_19 nanUNKNOWN
Prognositc Factors in COVID-19 Patients Complicated With Hypertension nanWITHDRAWN
Residual Renal Function Preservation in Peritoneal Dialysis Patients nanUNKNOWN
Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy nanCOMPLETED
The VALIDATE-D Study nanCOMPLETED
Effects of Traditional Chinese Medicine (GSJYF) in Children With Inherited Proteinuric Kidney Disease nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a REN binder may also engage these)

ProteinNameSimilarity
Q9TSZ1 — 1.000 Q9TSZ1 →
P60016 — 1.000 P60016 →
Q6DLS0 — 1.000 Q6DLS0 →
Q6DLW5 — 1.000 Q6DLW5 →
P08424 — 1.000 P08424 →
Q18DC9 — 0.998 Q18DC9 →
P52115 — 0.996 P52115 →
P00796 — 0.996 P00796 →
Q6DYE7 — 0.994 Q6DYE7 →
Q18DC8 — 0.994 Q18DC8 →
P06281 — 0.994 P06281 →
Q9XEC4 — 0.990 Q9XEC4 →
Q9XFX3 — 0.988 Q9XFX3 →
P24268 — 0.987 P24268 →
Q9XFX4 — 0.985 Q9XFX4 →
O04057 — 0.985 O04057 →
Q42456 — 0.985 Q42456 →
CTSD Cathepsin D 0.984 landscape →
Q9N9H4 — 0.984 Q9N9H4 →
Q21966 — 0.984 Q21966 →
P18242 — 0.984 P18242 →
Q8VYL3 — 0.984 Q8VYL3 →
Q9GK11 — 0.983 Q9GK11 →
P42211 — 0.983 P42211 →
Q8MYN5 — 0.982 Q8MYN5 →
Q28057 — 0.982 Q28057 →
P42210 — 0.982 P42210 →
P80209 — 0.981 P80209 →
Q28755 — 0.981 Q28755 →
Q4LAL9 — 0.981 Q4LAL9 →