Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15087907 | 1.00 | REN (0.37) | RENPDE4BKCNH2TACR1NR1H4 | |
| SCHEMBL90158 | 1.00 | REN (0.37) | RENPDE4BKCNH2TACR1NR1H4 | |
| SCHEMBL90379 | 0.95 | REN (0.45) | RENKCNH2 | |
| SCHEMBL90743 | 0.90 | PDE4B (0.39) | RENPDE4BKCNH2TACR1NR1H4 | |
| SCHEMBL90515 | 0.89 | REN (0.38) | RENKCNH2NR1H4 | |
| SCHEMBL90684 | 0.89 | REN (0.37) | RENPDE4BKCNH2TACR1NR1H4 | |
| SCHEMBL1911419 | 0.87 | REN (0.34) | RENPDE4B | |
| SCHEMBL89775 | 0.87 | REN (0.34) | RENPDE4B | |
| SCHEMBL89785 | 0.86 | REN (0.42) | RENKCNH2NR1H4 | |
| SCHEMBL90157 | 0.86 | REN (0.51) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |