Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911372 | 0.92 | REN (0.49) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL1911414 | 0.91 | REN (0.43) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL10283497 | 0.81 | KMT2A (0.42) | RENALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL89679 | 0.80 | REN (0.47) | RENALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL89766 | 0.78 | REN (0.62) | RENALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL1913344 | 0.78 | REN (0.53) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL90633 | 0.78 | REN (0.55) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL10283290 | 0.77 | REN (0.58) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL90645 | 0.77 | REN (0.58) | RENALDH1A1POLBGAAKMT2A | |
| SCHEMBL90632 | 0.77 | REN (0.57) | RENALDH1A1POLBGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |