SCHEMBL1028330

SCHEMBL1028330

C[Si](C)(C)C1C=Cc2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.39
HTR6 P50406 1/20 0.38
CYP2D6 P10635 3/20 0.35
KDM4E B2RXH2 2/20 0.35
BRD4 O60885 1/20 0.35
CCL2 P13500 1/20 0.35
LMNA P02545 1/20 0.35
TP53 P04637 1/20 0.35
CHRM2 P08172 1/20 0.35
CYP3A4 P08684 1/20 0.35
CHRM1 P11229 1/20 0.35
DRD2 P14416 1/20 0.35
ADRA2B P18089 1/20 0.35
ADRA2C P18825 1/20 0.35
NFKB1 P19838 1/20 0.35
CHRM3 P20309 1/20 0.35
SLC6A2 P23975 1/20 0.35
HTR2C P28335 1/20 0.35
ADRA1A P35348 1/20 0.35
HRH1 P35367 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9143099 0.98 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
Methane SCHEMBL28906839 0.98 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL9146253 0.98 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
Lithium SCHEMBL9146259 0.98 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL9143107 0.98 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
Ethylene SCHEMBL10454745 0.94 HTR2A (0.35) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL4652449 0.91 HTR2A (0.39) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL9148148 0.89 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL60904 0.89 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4
SCHEMBL1287993 0.89 HTR2A (0.38) HTR2AHTR6CYP2D6KDM4EBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110256622-B Reinforced and toughened syndiotactic polystyrene and preparation method thereof 中国科学院长春应用化学研究所 2021-03-16 CN claimed
EP-0993478-B2 OLEFIN POLYMERIZATION PROCESS BOREALIS TECH OY (FI) 2011-01-19 EP claimed
US-7186783-B2 Process for preparaing partially hydrogenated butadiene polymers KRATON POLYMERS U.S. LLC (US) 2007-03-06 US claimed
US-6921799-B1 Olefin polymerization process BOREALIS A/S (DK) 2005-07-26 US claimed
EP-1311561-B1 PROCESS FOR PREPARING PARTIALLY HYDROGENATED BUTADIENE POLYMERS KRATON POLYMERS RES BV (NL) 2005-06-08 EP claimed
EP-0993478-B1 OLEFIN POLYMERIZATION PROCESS BOREALIS TECH OY (FI) 2004-04-07 EP claimed
EP-1311561-A1 PROCESS FOR PREPARING PARTIALLY HYDROGENATED BUTADIENE POLYMERS KRATON Polymers Research B.V. (NL) 2003-05-21 EP claimed
US-20030092851-A1 Process for preparing partially hydrogenated butadiene polymers BANK OF AMERICA, N.A. 2003-05-15 US claimed
US-6399531-B1 COORDINATION CATALYST UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION 2002-06-04 US claimed
WO-2002034799-A1 PROCESS FOR PREPARING PARTIALLY HYDROGENATED BUTADIENE POLYMERS KRATON POLYMERS RESEARCH B.V. (NL) 2002-05-02 WO claimed
US-5670588-A TITANIUM, ZIRCONIUM, OR HAFNIUM COMPOUND, ORGANOCYCLIC HYDROCARBON OR SIICON COMPOUND, MODIFIED ORGANOALUMINUM COMPOUND NIPPON OIL CO., LTD. (JP) 1997-09-23 US claimed
WO-1996013532-A1 IN SITU DEHYDROXYLATION OF SUPPORTS AND PREPARATION OF SUPPORTED METALLOCENE POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 1996-05-09 WO claimed
CN-120157717-A Synthesis method of asymmetric metallocene catalyst 中国科学院大连化学物理研究所 2025-06-17 CN disclosed
CN-116410237-A Synthesis method of non-bridged symmetrical metallocene catalyst, product and application thereof 中国石油天然气股份有限公司 2023-07-11 CN disclosed
CN-110283280-B Metal complex catalyst, polymerization process using the same, and polymer product thereof 株式会社普利司通 2022-11-04 CN disclosed
CN-110256622-B Reinforced and toughened syndiotactic polystyrene and preparation method thereof 中国科学院长春应用化学研究所 2021-03-16 CN disclosed
EP-0520811-A2 Catalyst components for polymerization of olefins NIPPON OIL CO. LTD. (JP) 1992-12-30 EP disclosed
US-4985576-A Bisindenyl derivative, and a process for the preparation thereof HOECHST AKTIENGESELLSCHAFT (DE) 1991-01-15 US disclosed
US-4962253-A Vinylation of aromatics catalyzed by cyclopentadienyl, indenyl, or fluorenyl rhodium complexes, and novel indenyl and fluorenyl rhodium complexes THE DOW CHEMICAL COMPANY (US) 1990-10-09 US disclosed
EP-0376154-A2 Bisindenyl derivative and method for its preparation HOECHST AKTIENGESELLSCHAFT (DE) 1990-07-04 EP disclosed