Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 14/20 | 0.86 |
| ▸ | PRKAG1 | P54619 | 14/20 | 0.86 |
| ▸ | PRKAA2 | P54646 | 14/20 | 0.86 |
| ▸ | PRKAA1 | Q13131 | 14/20 | 0.86 |
| ▸ | PRKAG3 | Q9UGI9 | 14/20 | 0.86 |
| ▸ | PRKAG2 | Q9UGJ0 | 14/20 | 0.86 |
| ▸ | PRKAB1 | Q9Y478 | 14/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517986 | 0.92 | PRKAB2 (1.00) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518529 | 0.90 | PRKAA2 (0.90) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518679 | 0.87 | PRKAB2 (0.87) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518517 | 0.87 | PRKAA2 (1.00) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL16615397 | 0.86 | PRKAA2 (0.89) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL22268945 | 0.85 | PRKAA2 (0.81) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518740 | 0.85 | PRKAA2 (0.77) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL15171532 | 0.85 | PRKAB2 (0.84) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518414 | 0.85 | PRKAB2 (0.83) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518887 | 0.84 | PRKAA2 (0.92) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |