Sugi Predict

Sugi Predict / Targets / PRKAB2

PRKAB2

5'-AMP-activated protein kinase subunit beta-2 · O43741 · PRKAB2 on Sugi Atlas →

48,768 patent compounds predicted against PRKAB2, 29,794 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL518066 SCHEMBL518066 1.00 17/20
SCHEMBL518142 SCHEMBL518142 1.00 17/20
SCHEMBL518005 SCHEMBL518005 1.00 16/20
SCHEMBL518045 SCHEMBL518045 1.00 16/20
SCHEMBL518134 SCHEMBL518134 1.00 16/20
SCHEMBL518224 SCHEMBL518224 1.00 16/20
SCHEMBL518225 SCHEMBL518225 1.00 16/20
SCHEMBL518023 SCHEMBL518023 0.93 16/20
SCHEMBL518208 SCHEMBL518208 0.91 16/20
SCHEMBL517797 SCHEMBL517797 0.89 16/20
SCHEMBL517976 SCHEMBL517976 0.89 16/20
SCHEMBL518068 SCHEMBL518068 0.88 16/20
SCHEMBL518179 SCHEMBL518179 0.85 16/20
SCHEMBL517980 SCHEMBL517980 0.84 16/20
SCHEMBL517967 SCHEMBL517967 0.81 16/20
SCHEMBL518037 SCHEMBL518037 0.80 16/20
SCHEMBL518123 SCHEMBL518123 0.79 16/20
SCHEMBL518174 SCHEMBL518174 0.76 16/20
SCHEMBL518173 SCHEMBL518173 0.76 16/20
SCHEMBL517982 SCHEMBL517982 1.00 15/20

Clinical trials — most relevant to PRKAB2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity PHASE4COMPLETED
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS) PHASE4RECRUITING
Metformin Induces a Dietary Restriction-like State in Human PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
Metformin and Simvastatin Use in Bladder Cancer PHASE2UNKNOWN
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients PHASE2COMPLETED
Safety and Feasibility of Metformin for Sepsis Induced AKI PHASE2COMPLETED
Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease PHASE2COMPLETED
Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus PHASE2COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
PKC412 and 5-Azacytidine PHASE1/PHASE2COMPLETED
Metformin for Fibromyalgia Symptoms (INFORM Trial) PHASE2RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer PHASE1WITHDRAWN
Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. PHASE1COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Effect of Age on Glucose and Lipid Metabolism nanCOMPLETED
NASH AMPK Exercise Dosing (AMPED) Trial nanRECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Influence of Intermittent Hypoxia on Glycemic Control nanCOMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH nanCOMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
Exercise Effects on Cardiometabolic Health and Sestrin-2 in Hypertensive Obese Women nanNOT_YET_RECRUITING
Ischemia-reperfusion Exercise Study nanCOMPLETED
Study of Menstrual Irregularities and Endometrial Pathology in Women Undergoing Bariatric Surgery nanCOMPLETED
Muscle Wasting in Cancer (MWIC) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKAB2 binder may also engage these)

ProteinNameSimilarity
Q6PAM0 — 1.000 Q6PAM0 →
Q9QZH4 — 1.000 Q9QZH4 →
Q9NP50 — 0.949 Q9NP50 →
Q5RCB7 — 0.947 Q5RCB7 →
Q6AYU1 — 0.943 Q6AYU1 →
Q9ERA0 — 0.942 Q9ERA0 →
Q12800 — 0.941 Q12800 →
Q5ZJV7 — 0.940 Q5ZJV7 →
Q5NVP9 — 0.940 Q5NVP9 →
Q8C8M1 — 0.940 Q8C8M1 →
Q7RTP6 — 0.938 Q7RTP6 →
Q5BIS9 — 0.938 Q5BIS9 →
P60762 — 0.938 P60762 →
Q5RBN9 — 0.938 Q5RBN9 →
Q7Z6J6 — 0.936 Q7Z6J6 →
Q8CJ19 — 0.936 Q8CJ19 →
Q9TUZ0 — 0.935 Q9TUZ0 →
MORF4L1 Mortality factor 4-like protein 1 0.935 landscape →
Q6UXG2 — 0.935 Q6UXG2 →
Q86TJ2 — 0.935 Q86TJ2 →
Q7T2U9 — 0.935 Q7T2U9 →
Q5RBB8 — 0.935 Q5RBB8 →
O14639 — 0.934 O14639 →
Q6NRB5 — 0.934 Q6NRB5 →
Q9TUM3 — 0.933 Q9TUM3 →
Q6NZH6 — 0.933 Q6NZH6 →
Q5F450 — 0.933 Q5F450 →
SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 0.931 landscape →
Q5XIT1 — 0.931 Q5XIT1 →
STAT5B Signal transducer and activator of transcription 5B 0.930 landscape →