Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117378 | 0.80 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC11HDAC2 | |
| SCHEMBL2119872 | 0.72 | HDAC8 (0.46) | HDAC6HDAC1HDAC8HDAC11HDAC2 | |
| SCHEMBL17936605 | 0.69 | PDE7A (0.56) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2116566 | 0.69 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC11HDAC2 | |
| SCHEMBL7762374 | 0.69 | PDE7A (0.58) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2119122 | 0.69 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC11HDAC2 | |
| SCHEMBL4550115 | 0.69 | RXFP1 (0.69) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL2119910 | 0.68 | ALDH1A1 (0.62) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2611261 | 0.68 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC11HDAC2 | |
| SCHEMBL31542055 | 0.68 | NPC1 (0.70) | HDAC6HDAC1HDAC8HDAC11HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054332-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |