SCHEMBL10285334

SCHEMBL10285334

O=CCn1c(=O)ccc2c(N=O)cccc21

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
HPGD P15428 1/20 0.33
MAPK1 P28482 2/20 0.30
LMNA P02545 1/20 0.30
CRHBP P24387 1/20 0.30
HTT P42858 1/20 0.30
CRHR2 Q13324 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2798722 0.78 MAPK14 (0.43) ALDH1A1HPGDMAPK1LMNACRHBP
SCHEMBL2794275 0.78 ALDH1A1 (0.35) ALDH1A1HPGDMAPK14
SCHEMBL4303007 0.78 PTGER4 (0.39) ALDH1A1HPGDMAPK1LMNAHTT
SCHEMBL10285883 0.78 ALDH1A1 (0.38) ALDH1A1HPGDLMNAHTT
SCHEMBL2800336 0.75 TNFRSF1A (0.43) ALDH1A1
SCHEMBL2793596 0.70 CA12 (0.48) ALDH1A1HPGDMAPK1HTT
SCHEMBL2798307 0.70 CCNB2 (0.42) ALDH1A1HPGDMAPK1HTT
SCHEMBL13456337 0.67 CYP1A2 (0.56) ALDH1A1
SCHEMBL13607472 0.66 ALDH1A1 (0.60) ALDH1A1HPGDHTT
SCHEMBL10285545 0.66 ALDH1A1 (0.50) ALDH1A1HPGDLMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2468743-A1 Nitrogen-containing bicyclic compounds useful as antibacterial agents Toyama Chemical Co., Ltd. (JP) 2012-06-27 EP disclosed
EP-1900732-A1 NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2008-03-19 EP disclosed