SCHEMBL10286124

SCHEMBL10286124

CCOc1cc2c(nc1C)C(O)CCCC2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.36
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
CASP3 P42574 2/20 0.34
SENP8 Q96LD8 2/20 0.34
SENP7 Q9BQF6 2/20 0.34
SENP6 Q9GZR1 2/20 0.34
APOBEC3G Q9HC16 1/20 0.33
ALDH1A1 P00352 3/20 0.33
ATM Q13315 1/20 0.33
MAPT P10636 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2C19 P33261 2/20 0.33
CYP2C9 P11712 1/20 0.33
GAA P10253 3/20 0.32
TP53 P04637 1/20 0.32
GLA P06280 1/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HTT P42858 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10286196 0.84 MAOB (0.32)
SCHEMBL10286132 0.84 CHRM4 (0.38) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL7911353 0.82 KDM4E (0.52) KDM4ENPC1RAB9ACASP3SENP8
SCHEMBL10286146 0.80 GRM1 (0.37) KDM4ENPC1RAB9A
SCHEMBL10286054 0.80 CYP1A2 (0.37) KDM4ENPC1ALDH1A1MAPTCYP1A2
SCHEMBL10286140 0.79 UGT2B17 (0.37) KDM4ENPC1RAB9AALDH1A1HSD17B10
SCHEMBL7913313 0.77 KDM4E (0.50) KDM4ENPC1RAB9ACASP3SENP8
SCHEMBL10286314 0.77 RXFP1 (0.34) KDM4EAPOBEC3GALDH1A1MAPTCYP1A2
SCHEMBL10286269 0.75 GRM1 (0.38) KDM4EACHE
SCHEMBL10286195 0.74 UGT2B17 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2013-04-25 US disclosed
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2013-04-25 US disclosed
WO-2012001040-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130102631-A1 NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES MSR1, DDT, MPO KDM4E 1075/4885NPC1 3975/4885RAB9A 2972/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.