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MPO

Myeloperoxidase · P05164 · MPO on Sugi Atlas →

68,257 patent compounds predicted against MPO, 45,322 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL205462 SCHEMBL205462 0.60 14/20
SCHEMBL202865 SCHEMBL202865 0.57 14/20
SCHEMBL57463 SCHEMBL57463 0.56 14/20
SCHEMBL208748 SCHEMBL208748 0.55 11/20
Fluorotryptophane Fluorotryptophane (SCHEMBL122142) 0.66 7/20
Fluorotryptophane Fluorotryptophane (SCHEMBL125000) 0.66 7/20
Flufenamic Acid Flufenamic Acid (SCHEMBL17497) 0.73 6/20
SCHEMBL169275 SCHEMBL169275 0.57 6/20
SCHEMBL166339 SCHEMBL166339 0.55 6/20
SCHEMBL172713 SCHEMBL172713 0.51 6/20
SCHEMBL207031 SCHEMBL207031 0.49 5/20
Fantridone Fantridone (SCHEMBL124109) 0.58 4/20
SCHEMBL172293 SCHEMBL172293 0.57 4/20
Budralazine Budralazine (SCHEMBL49541) 0.57 4/20
SCHEMBL43837 SCHEMBL43837 0.54 4/20
SCHEMBL51747 SCHEMBL51747 0.52 4/20
SCHEMBL87816 SCHEMBL87816 0.52 4/20
SCHEMBL80668 SCHEMBL80668 0.51 4/20
SCHEMBL13763 SCHEMBL13763 0.51 4/20
SCHEMBL96466 SCHEMBL96466 0.47 4/20

Clinical trials — most relevant to MPO by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block PHASE4UNKNOWN
The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Randomized Controlled Clinical Trial PHASE4ACTIVE_NOT_RECRUITING
Use of Hypochlorous Acid as Prophylaxis in Health Personnel at High Risk of Infection by SARS-CoV 2 (COVID19) PHASE2/PHASE3WITHDRAWN
The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach PHASE3ACTIVE_NOT_RECRUITING
The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach PHASE3COMPLETED
Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease PHASE3NOT_YET_RECRUITING
Beneficial Effect of Silymarin in Ulcerative Colitis PHASE2RECRUITING
Pilot Study of Pirfenidone in Pulmonary Fibrosis With Anti-myeloperoxydase Antibodies PHASE2COMPLETED
Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS PHASE1UNKNOWN
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs EARLY_PHASE1COMPLETED
The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping nanACTIVE_NOT_RECRUITING
Analytical Performance of pH, HNE and MPO Levels in Detecting Wound Infection Proof of Concept Biomarker Study nanWITHDRAWN
The Use of Biochemical Analyzes to Monitor the Development of Wounds nanCOMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS nanCOMPLETED
Plasma Myeloperoxidase Levels in Patients With Coronary Artery Disease nanCOMPLETED
Evaluation of Anti-neutrophil Cytoplasm Antibodies Test nanUNKNOWN
Triage Now: an Observational, Prospective Multimarker Study of Biomarkers in Patients Presenting With Chest Pain nanCOMPLETED
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps) nanRECRUITING
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma nanCOMPLETED
Chocolate for Patients With Chronic Kidney Disease nanCOMPLETED
Ginkgo Biloba Extract for Schizophrenia nanCOMPLETED
Development and Prospective Validation of a Standardized Flow Cytometric Assay of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes. nanUNKNOWN
SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls nanUNKNOWN
Lung Mucus Hypersecretion and NQO1 nanCOMPLETED
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients nanCOMPLETED
Personalizing Preterm Neonatal Transfusions With Fetal Hemoglobin-Enriched Cord Blood nanNOT_YET_RECRUITING
Clinical and Biochemical Effects of a Defined Plant-Based Diet on Heart Disease nanRECRUITING
Pathological Myeloid Activation After Sepsis and Trauma nanRECRUITING
Biosensor and Environmental Sensor Development Within the REMEDIA Project nanCOMPLETED
Exercise and Arterial Stiffness in Systemic Lupus Erythematosus nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MPO binder may also engage these)

ProteinNameSimilarity
P11247 — 0.994 P11247 →
P49290 — 0.986 P49290 →
EPX Eosinophil peroxidase 0.984 landscape →
LPO Lactoperoxidase 0.960 landscape →
Q8R481 — 0.958 Q8R481 →
Q5SW46 — 0.953 Q5SW46 →
A0A452E9Y6 — 0.952 A0A452E9Y6 →
TPO Thyroid peroxidase 0.942 landscape →
A1KZ92 — 0.941 A1KZ92 →
Q8CIY2 — 0.939 Q8CIY2 →
Q9MZF4 — 0.938 Q9MZF4 →
Q8HZK2 — 0.938 Q8HZK2 →
Q9ES45 — 0.938 Q9ES45 →
Q01603 — 0.937 Q01603 →
P35419 — 0.936 P35419 →
Q8HZK3 — 0.936 Q8HZK3 →
DUOX2 Dual oxidase 2 0.936 landscape →
P09933 — 0.933 P09933 →
DUOX1 Dual oxidase 1 0.933 landscape →
A2AQ92 — 0.933 A2AQ92 →
Q9VQH2 — 0.933 Q9VQH2 →
P14650 — 0.932 P14650 →
Q8HYB7 — 0.931 Q8HYB7 →
Q23490 — 0.928 Q23490 →
Q2KIY5 — 0.923 Q2KIY5 →
P70669 — 0.923 P70669 →
P78562 — 0.921 P78562 →
Q4QQW8 — 0.921 Q4QQW8 →
Q3TCN2 — 0.919 Q3TCN2 →
ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 0.917 landscape →