Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 6/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 4/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688420 | 0.85 | PLK1 (0.48) | PLK1PLK2PLK3ATRPDE4D | |
| SCHEMBL1288336 | 0.80 | PLK1 (0.73) | PLK1PLK2PLK3 | |
| SCHEMBL5931036 | 0.80 | PLK1 (0.73) | PLK1PLK2PLK3 | |
| SCHEMBL1288780 | 0.78 | PLK1 (0.72) | PLK1PLK2PLK3 | |
| SCHEMBL1288784 | 0.78 | PLK1 (0.72) | PLK1PLK2PLK3 | |
| SCHEMBL6844840 | 0.77 | PLK1 (0.51) | PLK1PLK2PLK3ATRPDE4D | |
| SCHEMBL2689522 | 0.77 | PLK1 (0.47) | PLK1PLK2PLK3MTOR | |
| SCHEMBL2689499 | 0.77 | PLK1 (0.47) | PLK1PLK2PLK3MTOR | |
| SCHEMBL1288358 | 0.74 | PLK1 (0.58) | PLK1PLK2PLK3 | |
| SCHEMBL1688433 | 0.74 | PLK1 (0.45) | PLK1PLK2PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |