Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.51 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844686 | 0.81 | PLK1 (0.61) | PLK1PLK2PIK3CAMTORPLK3 | |
| SCHEMBL6844827 | 0.79 | PLK1 (0.60) | PLK1PLK2PIK3CAMTORPLK3 | |
| SCHEMBL1688420 | 0.78 | PLK1 (0.48) | PLK1PLK2PLK3ATRPDE4D | |
| SCHEMBL10286392 | 0.77 | PLK1 (0.49) | PLK1PLK2PIK3CAMTORPLK3 | |
| SCHEMBL6911355 | 0.75 | PLK1 (0.50) | PLK1PLK2PLK3 | |
| SCHEMBL2075063 | 0.71 | MTOR (0.55) | PIK3CAMTORNUDT1PIK3C3 | |
| SCHEMBL12006348 | 0.71 | MTOR (0.54) | PIK3CAMTORATRATRIP | |
| SCHEMBL2052447 | 0.71 | PLK1 (0.60) | PLK1PLK2MTORPLK3 | |
| SCHEMBL2048055 | 0.71 | PLK1 (0.60) | PLK1PLK2MTORPLK3 | |
| SCHEMBL2048059 | 0.71 | PLK1 (0.60) | PLK1PLK2MTORPLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |