Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 8/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824483 | 0.94 | CCR1 (0.54) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL13617098 | 0.94 | CCR1 (0.54) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14579622 | 0.91 | CCR1 (0.61) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10287608 | 0.91 | CCR1 (0.61) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14579586 | 0.90 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL12121530 | 0.90 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL14419957 | 0.90 | CCR1 (0.63) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL10288259 | 0.90 | CCR1 (0.58) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL13824477 | 0.90 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL14419959 | 0.90 | CCR1 (0.66) | CCR1CHRM2CCR5HRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653096-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20120046311-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-7271176-B2 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046311-A1 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF | ACKR3, CCR2, CXCR2 | CCR1 9/4885CHRM2 747/4885CCR5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.