Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 20/20 | 1.00 |
| ▸ | HRH1 | P35367 | 4/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365598 | 0.87 | HRH4 (0.80) | HRH4HRH1HRH3 | |
| SCHEMBL1032182 | 0.85 | HRH4 (1.00) | HRH4HRH1HRH3 | |
| SCHEMBL28012728 | 0.84 | HRH4 (0.76) | HRH4HRH1HRH3 | |
| SCHEMBL3366702 | 0.83 | HRH4 (0.78) | HRH4HRH1HRH3 | |
| SCHEMBL1030430 | 0.82 | HRH4 (1.00) | HRH4HRH1HRH3KCNH2 | |
| SCHEMBL3364869 | 0.81 | HRH4 (0.80) | HRH4HRH1HRH3 | |
| SCHEMBL3362883 | 0.81 | HRH4 (0.75) | HRH4HRH1HRH3 | |
| SCHEMBL3366964 | 0.81 | HRH4 (0.75) | HRH4HRH1HRH3 | |
| SCHEMBL1029472 | 0.80 | HRH4 (1.00) | HRH4HRH1HRH3KCNH2 | |
| SCHEMBL1031103 | 0.80 | HRH4 (1.00) | HRH4HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270002-A1 | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2011-01-05 | — | — | EP | claimed |
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | claimed |
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| EP-2858647-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013182711-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2013-12-12 | — | — | WO | disclosed |
| EP-2270002-A1 | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2011-01-05 | — | — | EP | disclosed |
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |