Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.75 |
| ▸ | HRH1 | P35367 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.64 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032182 | 0.86 | HRH4 (1.00) | HRH4HRH1HRH3 | |
| SCHEMBL3365598 | 0.85 | HRH4 (0.80) | HRH4HRH1HRH3 | |
| SCHEMBL3366702 | 0.84 | HRH4 (0.78) | HRH4HRH1HRH3 | |
| SCHEMBL3362883 | 0.82 | HRH4 (0.75) | HRH4HRH1HRH3 | |
| SCHEMBL1028892 | 0.81 | HRH4 (1.00) | HRH4HRH1HRH3 | |
| SCHEMBL28012728 | 0.80 | HRH4 (0.76) | HRH4HRH1HRH3 | |
| SCHEMBL3364869 | 0.80 | HRH4 (0.80) | HRH4HRH1HRH3 | |
| SCHEMBL3366750 | 0.80 | HRH4 (0.71) | HRH4HRH1HRH3 | |
| SCHEMBL1034436 | 0.78 | HRH4 (1.00) | HRH4HRH1HRH3 | |
| SCHEMBL1031103 | 0.78 | HRH4 (1.00) | HRH4HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |