Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379822 | 0.86 | HSD11B1 (0.50) | KDM4EHSD17B10KMT2APDE2APDE10A | |
| SCHEMBL379692 | 0.83 | HSD11B1 (0.52) | KDM4EHSD17B10KMT2APDE2APDE10A | |
| SCHEMBL13385743 | 0.75 | HSD11B1 (0.53) | KDM4EPDE2APDE10AMAPK13HSD11B1 | |
| SCHEMBL2021978 | 0.73 | FLT1 (0.45) | KDM4EHSD17B10KMT2APDE2APDE10A | |
| SCHEMBL10288932 | 0.71 | HSD11B1 (0.47) | KDM4EHSD17B10KMT2AMAPK13CLK4 | |
| SCHEMBL3623290 | 0.71 | HSD11B1 (0.47) | KDM4EHSD17B10KMT2APDE2APDE10A | |
| SCHEMBL379749 | 0.71 | HSD11B1 (0.48) | KDM4EHSD17B10KMT2APDE2APDE10A | |
| SCHEMBL3277411 | 0.70 | MAPK13 (0.47) | KMT2AMAPK13MAP4K2 | |
| SCHEMBL2747248 | 0.69 | HSD11B1 (0.78) | PDE2APDE10AHSD11B1LMNAGAA | |
| SCHEMBL10288930 | 0.69 | DNMT1 (0.49) | KDM4EHSD17B10PDE2APDE10AMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-B1 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC (US) | 2012-01-25 | — | — | EP | disclosed |