Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | UBE2N | P61088 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289083 | 0.84 | MAPT (0.68) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL16844168 | 0.83 | KMT2A (0.73) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2723919 | 0.81 | TP53 (0.73) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2722164 | 0.80 | POLB (0.82) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2722837 | 0.80 | MAPT (0.79) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2723282 | 0.76 | MAPT (1.00) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2722489 | 0.76 | MAPT (0.87) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL10289179 | 0.76 | KMT2A (0.74) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL15209399 | 0.75 | KMT2A (0.62) | MAPTKMT2ALMNANPSR1HTT | |
| SCHEMBL2722586 | 0.75 | KMT2A (0.65) | MAPTKMT2ALMNANPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | disclosed |