Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723919 | 0.91 | TP53 (0.73) | KMT2AMAPTKDM4ELMNATP53 | |
| SCHEMBL2723282 | 0.85 | MAPT (1.00) | KMT2AMAPTKDM4ELMNATP53 | |
| SCHEMBL10289179 | 0.84 | KMT2A (0.74) | KMT2AMAPTKDM4ELMNATP53 | |
| SCHEMBL2722837 | 0.84 | MAPT (0.79) | KMT2AMAPTKDM4ELMNAUSP2 | |
| SCHEMBL10289177 | 0.83 | MAPT (0.62) | KMT2AMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL10289083 | 0.82 | MAPT (0.68) | KMT2AMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL3868831 | 0.80 | GAA (0.91) | MAPTKDM4ELMNATP53ALDH1A1 | |
| SCHEMBL25482008 | 0.80 | L3MBTL1 (0.78) | KMT2AMAPTLMNAUSP2ALDH1A1 | |
| SCHEMBL25482005 | 0.80 | TDP1 (0.70) | KMT2AMAPTLMNATP53USP2 | |
| SCHEMBL25482034 | 0.79 | ALDH1A1 (0.82) | KMT2AMAPTLMNAUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2886120-A1 | Quinazoline derivatives, compositions and uses related thereto | Emory University (US) | 2015-06-24 | — | — | EP | disclosed |