Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403540 | 0.92 | BRD4 (0.62) | BRD4POLBP2RX7KDM4ETDP1 | |
| SCHEMBL455687 | 0.85 | KDM4E (0.59) | POLBP2RX7KDM4ETDP1ALOX15 | |
| SCHEMBL10289415 | 0.84 | KDM4E (0.68) | BRD4POLBKDM4ETDP1ALOX15 | |
| SCHEMBL30380244 | 0.84 | KDM4E (0.68) | BRD4POLBKDM4ETDP1ALOX15 | |
| Hydrochloric Acid SCHEMBL27613793 | 0.83 | KDM4E (0.56) | POLBP2RX7KDM4ETDP1ALOX15 | |
| SCHEMBL6641842 | 0.83 | KDM4E (0.56) | POLBP2RX7KDM4ETDP1ALOX15 | |
| SCHEMBL24638170 | 0.82 | BRD4 (0.54) | BRD4POLBP2RX7KDM4ETDP1 | |
| SCHEMBL30380080 | 0.82 | BRD4 (0.54) | BRD4POLBP2RX7KDM4ETDP1 | |
| SCHEMBL18246383 | 0.82 | P2RX7 (0.68) | BRD4POLBP2RX7KDM4ETDP1 | |
| SCHEMBL18519145 | 0.82 | P2RX7 (0.68) | POLBP2RX7KDM4ETDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953148-B1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-02-29 | — | — | EP | disclosed |