Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 4/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714712 | 0.90 | SCN9A (0.40) | SCN9AGLSCCR3GSK3BMAPT | |
| SCHEMBL2715870 | 0.89 | SCN9A (0.47) | SCN9AGLSCCR3ABL1IRAK4 | |
| SCHEMBL2713376 | 0.81 | SCN9A (0.52) | SCN9ACCR3GSK3BMAPTRIPK1 | |
| SCHEMBL2716501 | 0.81 | SCN9A (0.44) | SCN9AGSK3BMAPTRIPK1KDM4E | |
| SCHEMBL2713603 | 0.79 | CCR3 (0.41) | SCN9ACCR3GSK3BMAPTABL1 | |
| SCHEMBL2715702 | 0.79 | SCN9A (0.41) | SCN9ACCR3GSK3BMAPT | |
| SCHEMBL2717384 | 0.79 | SCN9A (0.43) | SCN9AGLSCCR3GSK3BABL1 | |
| SCHEMBL2713122 | 0.78 | SCN9A (0.48) | SCN9ACCR3GSK3BMAPTCCNE1 | |
| SCHEMBL2714871 | 0.78 | SCN9A (0.39) | SCN9ACCR3GSK3BCCNE1CDK2 | |
| SCHEMBL2716161 | 0.78 | SCN9A (0.47) | SCN9ACCR3GSK3BMAPTABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053186-A1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-04-26 | — | — | WO | disclosed |