Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878924 | 0.93 | KDR (0.42) | KDRBRAFRIPK1KITFLT3 | |
| SCHEMBL879093 | 0.90 | KDR (0.43) | KDRPDGFRBBRAFRIPK1HTR2A | |
| SCHEMBL878947 | 0.83 | KDR (0.41) | KDRBRAFRIPK1KITFLT3 | |
| SCHEMBL10290356 | 0.81 | KDR (0.40) | KDRPDGFRBBRAFRIPK1KIT | |
| SCHEMBL10291001 | 0.81 | AXL (0.40) | KDRPDGFRBBRAFRIPK1HTR2A | |
| SCHEMBL878946 | 0.80 | RET (0.41) | BRAFTEKRIPK1FLT3BCR | |
| SCHEMBL60144 | 0.79 | ACVRL1 (0.56) | KDRPDGFRBBRAFTEKRIPK1 | |
| SCHEMBL879122 | 0.79 | MCHR1 (0.41) | HTR2AHTR2C | |
| SCHEMBL878901 | 0.77 | AXL (0.46) | KDRPDGFRBBRAFTEKRIPK1 | |
| SCHEMBL878967 | 0.76 | KDR (0.45) | KDRPDGFRBBRAFTEKRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100063038-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis | BAYER HEALTHCARE LLC | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063038-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis | CDK4, CDKL4, MKI67 | KDR 41/4885PDGFRB 453/4885BRAF 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.