ACVRL1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL59573	0.65	20/20
SCHEMBL83255	0.58	19/20
SCHEMBL59716	0.52	18/20
SCHEMBL65394	0.50	18/20
SCHEMBL59980	0.63	16/20
SCHEMBL56767	0.58	16/20
SCHEMBL66531	0.55	16/20
SCHEMBL58580	0.50	16/20
SCHEMBL60270	0.50	16/20
SCHEMBL59418	0.82	15/20
SCHEMBL60341	0.74	15/20
SCHEMBL59788	0.69	15/20
SCHEMBL58645	0.61	15/20
SCHEMBL64684	0.51	15/20
SCHEMBL456393	1.00	14/20
SCHEMBL59483	0.76	14/20
SCHEMBL58556	0.64	14/20
SCHEMBL59792	0.79	13/20
SCHEMBL65830	0.79	13/20
SCHEMBL60264	0.58	13/20

Clinical trials — most relevant to ACVRL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients	PHASE3	UNKNOWN
Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological Malignancies	PHASE2/PHASE3	NOT_YET_RECRUITING
Bevacizumab With or Without TRC105 in Treating Patients With Metastatic Kidney Cancer	PHASE2	COMPLETED
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor	PHASE1/PHASE2	COMPLETED
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)	PHASE2	COMPLETED
Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer	PHASE2	COMPLETED
Dalantercept in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer	PHASE2	COMPLETED
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	PHASE1	COMPLETED
A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults	PHASE1	NOT_YET_RECRUITING
ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy	PHASE1	COMPLETED
Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension	nan	UNKNOWN
Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension	nan	COMPLETED
Influence of Hypoxic Induced Factors in Patients With Hereditary Hemorrhagic Telangiectasia	nan	RECRUITING
Luspatercept in Metastatic AGCT of the Ovary	nan	COMPLETED
Genotype-phenotype Association in Hereditary Hemorrhagic Telangiectasia	nan	COMPLETED
Urinary Activin A as Apredictive Marker for Assessement of Acute Kidney Injury Severity in Patient Admitted at Assuit University Hospital	nan	NOT_YET_RECRUITING
Screening of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers	nan	COMPLETED
Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.	nan	RECRUITING
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
StratosPHere (Non-interventional Study)	nan	COMPLETED
The PAH Platform for Deep Phenotyping in Korean Subjects	nan	UNKNOWN
Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension	nan	ACTIVE_NOT_RECRUITING
Influence of Sarcopenia on the Course of the Diseases	nan	RECRUITING
Study of Tissue, Blood, and Urine Samples From Patients With Advanced Prostate Cancer	nan	UNKNOWN
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis	nan	UNKNOWN
European Registry of Acutely Decompensated Pulmonary Arterial Hypertension	nan	NOT_YET_RECRUITING
National Cohort Study of Idiopathic and Heritable Pulmonary Arterial Hypertension	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ACVRL1 binder may also engage these)

Protein	Name	Similarity
Q5RAN0	—	1.000	Q5RAN0 →
P80203	—	1.000	P80203 →
Q61288	—	1.000	Q61288 →
Q05438	—	0.993	Q05438 →
Q61271	—	0.991	Q61271 →
P80202	—	0.991	P80202 →
BMPR1B	Bone morphogenetic protein receptor type-1B	0.991	landscape →
P70539	—	0.988	P70539 →
Q64729	—	0.987	Q64729 →
Q90ZK6	—	0.987	Q90ZK6 →
P80204	—	0.986	P80204 →
O46680	—	0.986	O46680 →
TGFBR1	TGF-beta receptor type-1	0.985	landscape →
P80201	—	0.984	P80201 →
Q8NER5	—	0.984	Q8NER5 →
Q8K348	—	0.984	Q8K348 →
Q28041	—	0.984	Q28041 →
P51839	—	0.984	P51839 →
P37172	—	0.984	P37172 →
Q63474	—	0.983	Q63474 →
ACVR1B	Activin receptor type-1B	0.983	landscape →
Q78EA7	—	0.983	Q78EA7 →
Q5CD18	—	0.983	Q5CD18 →
EPHB4	Ephrin type-B receptor 4	0.981	landscape →
P51840	—	0.981	P51840 →
Q99ML2	—	0.981	Q99ML2 →
P70218	—	0.981	P70218 →
Q498D6	—	0.980	Q498D6 →
Q03146	—	0.980	Q03146 →
P0C0K6	—	0.980	P0C0K6 →