Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.64 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.41 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16808325 | 0.90 | SLC34A2 (0.79) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL18040407 | 0.88 | SLC34A2 (0.75) | SLC34A2GPR52ROCK2ROCK1MAPK14 | |
| SCHEMBL47055 | 0.87 | SLC34A2 (0.82) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL6001829 | 0.87 | SLC34A2 (0.82) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL46770 | 0.87 | SLC34A2 (0.82) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL44914 | 0.87 | SLC34A2 (0.82) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL15432903 | 0.85 | SLC34A2 (0.70) | SLC34A2GPR52ROCK2ROCK1SCD | |
| SCHEMBL15444480 | 0.85 | SLC34A2 (0.70) | SLC34A2GPR52ROCK2ROCK1MAPK14 | |
| SCHEMBL10290125 | 0.84 | SLC34A2 (0.70) | SLC34A2GPR52ROCK2ROCK1LMNA | |
| SCHEMBL19595880 | 0.84 | SLC34A2 (0.75) | SLC34A2GPR52ROCK2ROCK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |