Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10257329 | 0.89 | MMP8 (0.46) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10290781 | 0.86 | MAPT (0.40) | MEN1KMT2ANPC1LMNAMAPT | |
| SCHEMBL511600 | 0.83 | MAPT (0.50) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL511601 | 0.83 | MAPT (0.50) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27652260 | 0.80 | MMP8 (0.54) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL17653672 | 0.80 | MMP8 (0.54) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16672673 | 0.80 | MMP8 (0.54) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL16672581 | 0.79 | MMP8 (0.50) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10291182 | 0.79 | MMP8 (0.44) | MMP8PIN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28001950 | 0.78 | MMP8 (0.49) | MMP8PIN1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103297-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-08-02 | — | — | WO | disclosed |
| WO-2011014535-A1 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-03 | — | — | WO | disclosed |