MMP8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ilomastat (SCHEMBL35303)	1.00	14/20
SCHEMBL26434	0.57	7/20
Marimastat (SCHEMBL34033)	1.00	6/20
Prinomastat (SCHEMBL115696)	1.00	6/20
SCHEMBL24140	0.56	6/20
Sulfluramid (SCHEMBL26873)	0.55	6/20
SCHEMBL23932	0.54	6/20
SCHEMBL73684	0.50	6/20
SCHEMBL107276	0.58	5/20
SCHEMBL54207	0.46	5/20
Foscarnet (SCHEMBL7637)	0.37	5/20
Batimastat (SCHEMBL4332)	1.00	4/20
Batimastat (SCHEMBL4333)	1.00	4/20
SCHEMBL45019	0.55	4/20
SCHEMBL92821	0.54	4/20
Butethal (SCHEMBL44262)	0.53	4/20
SCHEMBL76309	0.50	4/20
SCHEMBL55573	0.48	4/20
SCHEMBL56008	0.48	4/20
SCHEMBL57180	0.48	4/20

Clinical trials — most relevant to MMP8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol	PHASE4	COMPLETED
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis	PHASE2	COMPLETED
Roflumilast in Non-CF Bronchiectasis Study (2019)	PHASE2	COMPLETED
Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment	PHASE2	UNKNOWN
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
Safety and Tolerability Study of Allogeneic Mesenchymal Stem Cell Infusion in Adults With Cystic Fibrosis	PHASE1	COMPLETED
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
Peri-implantitis and MMP-8	nan	COMPLETED
The Effects of Sodium Fluoride and Chlorhexidine Use on Salivary IL-6 and Matrix Metalloproteinase Levels in Children With Active Caries	nan	RECRUITING
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Diagnostic Accuracy of Rapid Non-clinical Screening Tests for Early Detection of Periodontitis	nan	COMPLETED
The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity	nan	WITHDRAWN
Characterization of Pulp Inflammation: an Observational Study Using Biological Samples Collected During Routine Dental Care	nan	NOT_YET_RECRUITING
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum	nan	COMPLETED
Pathology, Venous Disease, and Clinical Correlations	nan	UNKNOWN
Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics	nan	NOT_YET_RECRUITING
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery	nan	COMPLETED
Cimzia Treatment in Rheumatoid Arthritis: Randomizing to Stop Versus Continue Disease-modifying Anti-rheumatic Drug(s)	nan	UNKNOWN
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Efficacy Study of Ultrasound-Assisted Debridement to Influence Wound Healing	nan	COMPLETED
Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease	nan	COMPLETED
Minimally Invasive Kidney Transplantation	nan	UNKNOWN
The Impact of Triptan and Doxycycline on Neuroinflammatory Biomarkers in Acute Migraine	nan	WITHDRAWN
Biomarkers for Prognosis of Glioblastoma (GBM)	nan	COMPLETED
Exhaled Nitric Oxide and Nasal Lavage Fluid	nan	COMPLETED
Plasma and Scarring of Diabetic Ulcers	nan	COMPLETED
Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MMP8 binder may also engage these)

Protein	Name	Similarity
O70138	—	1.000	O70138 →
O88766	—	1.000	O88766 →
MMP1	Interstitial collagenase	1.000	landscape →
Q9EPL5	—	1.000	Q9EPL5 →
Q6Y4Q5	—	1.000	Q6Y4Q5 →
P28053	—	1.000	P28053 →
P21692	—	1.000	P21692 →
Q10835	—	1.000	Q10835 →
P53690	—	1.000	P53690 →
O13065	—	1.000	O13065 →
P57748	—	1.000	P57748 →
Q10739	—	0.999	Q10739 →
Q95220	—	0.999	Q95220 →
MMP12	Macrophage metalloelastase	0.999	landscape →
O18767	—	0.999	O18767 →
P07152	—	0.999	P07152 →
MMP3	Stromelysin-1	0.998	landscape →
O55123	—	0.998	O55123 →
Q63341	—	0.997	Q63341 →
MMP14	Matrix metalloproteinase-14	0.997	landscape →
P28863	—	0.997	P28863 →
Q9GLE4	—	0.997	Q9GLE4 →
Q5RES1	—	0.997	Q5RES1 →
Q9GKE1	—	0.997	Q9GKE1 →
P34960	—	0.996	P34960 →
MMP20	Matrix metalloproteinase-20	0.996	landscape →
P13943	—	0.995	P13943 →
Q28397	—	0.995	Q28397 →
Q9XSZ5	—	0.995	Q9XSZ5 →
P50757	—	0.995	P50757 →