Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073298 | 0.95 | HDAC6 (0.54) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL2277596 | 0.83 | HDAC6 (0.58) | HDAC6HDAC8HDAC1HDAC3POLB | |
| SCHEMBL1027140 | 0.80 | HDAC6 (0.62) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL1082437 | 0.80 | TMEM97 (0.64) | HDAC6HDAC8HDAC1HDAC3TMEM97 | |
| SCHEMBL2275604 | 0.79 | HDAC6 (0.42) | HDAC6HDAC8TMPRSS2POLBTMEM97 | |
| SCHEMBL2283261 | 0.79 | HDAC6 (0.53) | HDAC6HDAC8HDAC1HDAC3POLB | |
| SCHEMBL1027560 | 0.78 | HDAC6 (0.73) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL1081445 | 0.75 | HDAC6 (0.70) | HDAC6HDAC8HDAC1HDAC3TMPRSS2 | |
| SCHEMBL8264660 | 0.75 | ABHD6 (0.56) | POLBTMEM97SIGMAR1 | |
| SCHEMBL2283593 | 0.75 | MAP3K5 (0.39) | HDAC6TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274283-A1 | NOVEL N-SUBSTITUTED TETRAHYDROISOQUINOLINE/ISOINDOLINE HYDROXAMIC ACID COMPOUNDS | 4SC AG (DE) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009112550-A1 | NOVEL N-SUBSTITUTED TETRAHYDROISOQUINOLINE/ISOINDOLINE HYDROXAMIC ACID COMPOUNDS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |