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Sugi Predict / Targets / ABHD6

ABHD6

Monoacylglycerol lipase ABHD6 · Q9BV23 · ABHD6 on Sugi Atlas →

22,845 patent compounds predicted against ABHD6, 11,997 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL772680 SCHEMBL772680 0.69 12/20
SCHEMBL587897 SCHEMBL587897 0.69 10/20
SCHEMBL745324 SCHEMBL745324 0.64 8/20
SCHEMBL908981 SCHEMBL908981 0.52 8/20
SCHEMBL424359 SCHEMBL424359 0.49 8/20
SCHEMBL507676 SCHEMBL507676 0.43 8/20
SCHEMBL1550147 SCHEMBL1550147 0.60 7/20
SCHEMBL507579 SCHEMBL507579 0.36 7/20
SCHEMBL419896 SCHEMBL419896 0.68 6/20
SCHEMBL1787936 SCHEMBL1787936 0.60 6/20
SCHEMBL952264 SCHEMBL952264 0.44 6/20
SCHEMBL507349 SCHEMBL507349 0.43 6/20
SCHEMBL507085 SCHEMBL507085 0.40 6/20
SCHEMBL507012 SCHEMBL507012 0.36 6/20
SCHEMBL585650 SCHEMBL585650 0.68 5/20
SCHEMBL588285 SCHEMBL588285 0.65 5/20
SCHEMBL350911 SCHEMBL350911 0.45 5/20
SCHEMBL506963 SCHEMBL506963 0.45 5/20
SCHEMBL507017 SCHEMBL507017 0.36 5/20
SCHEMBL587847 SCHEMBL587847 0.64 4/20

Clinical trials — most relevant to ABHD6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Omega-3 Fatty Acids on the Human Gene Expression PHASE4COMPLETED
Betaine and Peroxisome Biogenesis Disorders PHASE3COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Sebelipase Alfa in Children With Growth Failure Due to Lysosomal Acid Lipase Deficiency PHASE2/PHASE3COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Insulin Regulation of Lipolysis and Lipolysis Proteins EARLY_PHASE1RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans nanCOMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Circadian Rhythms in Human Adipose nanRECRUITING
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Lipodystrophy Connect Patient Registry nanCOMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing nanCOMPLETED
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise nanCOMPLETED
Role of Dairy Products in Weight Maintenance nanCOMPLETED
Use of MCT Oil for Enhancement of Weight Loss in Obese Patients nanCOMPLETED
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
Personalized or Precision Medicine in the Dietary Approach to Obesity nanUNKNOWN
Production of Free Fatty Acids From Blood Triglycerides nanCOMPLETED
Acute Fatty Acid Intervention Study (AFAST) nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Kuwait Adult Diabetes Epidemiological Multidisciplinary (KADEM) Program nanRECRUITING
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans nanCOMPLETED
An Analysis of Lipid and Glucose Metabolism Following Bariatric Surgery nanCOMPLETED
Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids nanUNKNOWN
Genetic Determinants:Low HDL, High Triglycerides, Obesity nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ABHD6 binder may also engage these)

ProteinNameSimilarity
Q8R2Y0 — 1.000 Q8R2Y0 →
Q6GLL2 — 1.000 Q6GLL2 →
Q1LZ86 — 1.000 Q1LZ86 →
Q7SY73 — 1.000 Q7SY73 →
Q5XI64 — 0.997 Q5XI64 →
Q8TB40 — 0.981 Q8TB40 →
Q802V6 — 0.979 Q802V6 →
Q4R2Y9 — 0.979 Q4R2Y9 →
Q8VD66 — 0.979 Q8VD66 →
ABHD5 1-acylglycerol-3-phosphate O-acyltransferase 0.978 landscape →
Q5EA59 — 0.978 Q5EA59 →
P08910 — 0.977 P08910 →
Q5RBI4 — 0.977 Q5RBI4 →
Q5EA42 — 0.977 Q5EA42 →
Q05AK6 — 0.976 Q05AK6 →
Q9DBL9 — 0.976 Q9DBL9 →
Q8VE09 — 0.976 Q8VE09 →
P0DKC6 — 0.975 P0DKC6 →
P0DKC5 — 0.975 P0DKC5 →
Q9DBE8 — 0.975 Q9DBE8 →
Q9QXM0 — 0.974 Q9QXM0 →
A0A1D6NER6 — 0.973 A0A1D6NER6 →
Q5EE05 — 0.973 Q5EE05 →
Q3U213 — 0.972 Q3U213 →
Q5HZX7 — 0.972 Q5HZX7 →
Q9SK66 — 0.972 Q9SK66 →
Q80YE7 — 0.972 Q80YE7 →
A2A7Z8 — 0.972 A2A7Z8 →
Q92503 — 0.972 Q92503 →
Q6QA69 — 0.972 Q6QA69 →