Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | EDNRA | P25101 | 1/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.57 |
| ▸ | FABP7 | O15540 | 6/20 | 0.56 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | FABP3 | P05413 | 3/20 | 0.55 |
| ▸ | P4HB | P07237 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643008 | 1.00 | POLB (0.64) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL8932091 | 0.97 | POLB (0.62) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL20614651 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL20598122 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL18674152 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL4560501 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL3482659 | 0.95 | HDAC4 (0.61) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL21120223 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL3482620 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 | |
| SCHEMBL15590565 | 0.95 | POLB (0.70) | POLBALDH1A1GAAEDNRAGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814855-B1 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-19 | — | — | EP | disclosed |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | BOEHRINGER MARKUS | 2009-10-29 | — | — | US | disclosed |
| US-7501413-B2 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1814855-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-08-08 | — | — | EP | disclosed |
| US-20060106016-A1 | Dicarboxamide derivatives | HOFFMANN-LA ROCHE INC. | 2006-05-18 | — | — | US | disclosed |
| WO-2006048152-A2 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106016-A1 | Dicarboxamide derivatives | F2, F12, TFPI | POLB 3769/4885ALDH1A1 1180/4885GAA 757/4885 |
| US-20090270360-A1 | DICARBOXAMIDE DERIVATIVES | F2, F12, TFPI | POLB 3769/4885ALDH1A1 1180/4885GAA 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.