Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11990856 | 0.88 | KMT2A (0.43) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10292544 | 0.88 | KMT2A (0.42) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10292542 | 0.88 | KMT2A (0.44) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10003686 | 0.87 | PTGES (0.48) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10004586 | 0.86 | KMT2A (0.48) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL11990823 | 0.86 | KMT2A (0.42) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL11990855 | 0.85 | KMT2A (0.47) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10292545 | 0.85 | KMT2A (0.43) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10292840 | 0.85 | PTGES (0.43) | KMT2APTGESPOLBALDH1A1TP53 | |
| SCHEMBL10292547 | 0.85 | POLB (0.44) | KMT2APTGESPOLBALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471793-B1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-10-05 | — | — | EP | disclosed |
| EP-2471793-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-07-04 | — | — | EP | disclosed |