PTGES — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Lonazolac (SCHEMBL25221)	0.86	9/20
Lonazolac (SCHEMBL287156)	0.84	9/20
SCHEMBL134594	0.46	9/20
SCHEMBL170216	0.76	5/20
SCHEMBL304251	0.53	5/20
SCHEMBL213604	0.45	5/20
SCHEMBL348377	0.44	5/20
SCHEMBL54526	0.39	5/20
Lanosterol (SCHEMBL145834)	0.79	4/20
Lanosterol (SCHEMBL145835)	0.79	4/20
Lanosterol (SCHEMBL244737)	0.79	4/20
Lanosterol (SCHEMBL288191)	0.79	4/20
Lanosterol (SCHEMBL288749)	0.79	4/20
Lanosterol (SCHEMBL288881)	0.79	4/20
SCHEMBL192284	0.66	4/20
SCHEMBL192285	0.66	4/20
SCHEMBL299527	0.60	4/20
SCHEMBL214871	0.59	4/20
SCHEMBL303907	0.59	4/20
SCHEMBL303420	0.58	4/20

Clinical trials — most relevant to PTGES by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
n-3 Polysaturated Fatty Acids-rich Diet in Psoriasis	PHASE4	COMPLETED
A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus	PHASE4	COMPLETED
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis and Inadequate Response to ≥2 NSAIDs	PHASE3	COMPLETED
Addition of Aspirin to Standard of Care in Oral Cancer	PHASE2/PHASE3	COMPLETED
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA	PHASE2/PHASE3	COMPLETED
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar	PHASE2/PHASE3	UNKNOWN
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Desloratadine,Phenylephrine Hcl,Ibuprofen Compared to Placebo in Treatment of Symptoms Associated With Common Cold/Flu	PHASE3	SUSPENDED
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus	PHASE2	UNKNOWN
Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention	PHASE2	COMPLETED
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)	PHASE2	COMPLETED
Adjunctive Celecoxib in Childhood-onset OCD Study	PHASE2	UNKNOWN
Vitamin E Supplements in Preventing Cancer in Patients at Risk of Prostate Cancer or Who Have Prostate Cancer	PHASE1	COMPLETED
Pathways of Eicosanoid Metabolism	EARLY_PHASE1	ENROLLING_BY_INVITATION
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture	nan	UNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates	nan	RECRUITING
Urinary PGE-MUM (PROSTAGLANDIN E-MAJOR URINARY METABOLITE) as Inflammatory Marker in Chronic Inflammatory Bowel Disease	nan	COMPLETED
Celebrex Premedication in Teeth With Symptomatic Irreversible Pulpitis	nan	UNKNOWN
Eicosanoids in Human Heart Failure	nan	UNKNOWN
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).	nan	RECRUITING
Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)	nan	COMPLETED
A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat AS	nan	UNKNOWN
Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation	nan	NOT_YET_RECRUITING
Cyclooxygenase Levels Following Surgery to Remove Third Molars (Wisdom Teeth)	nan	COMPLETED
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PTGES binder may also engage these)

Protein	Name	Similarity
Q6PWL6	—	1.000	Q6PWL6 →
Q9JM51	—	1.000	Q9JM51 →
Q9JHF3	—	1.000	Q9JHF3 →
Q8HZJ2	—	1.000	Q8HZJ2 →
Q95L14	—	0.999	Q95L14 →
A0SYQ0	—	0.999	A0SYQ0 →
MGST1	Microsomal glutathione S-transferase 1	0.997	landscape →
Q64L89	—	0.997	Q64L89 →
Q91VS7	—	0.992	Q91VS7 →
P79382	—	0.991	P79382 →
P08011	—	0.989	P08011 →
Q99735	—	0.989	Q99735 →
P73795	—	0.982	P73795 →
Q60860	—	0.980	Q60860 →
A2RST1	—	0.980	A2RST1 →
Q2KJG4	—	0.980	Q2KJG4 →
A6XA80	—	0.975	A6XA80 →
Q925U2	—	0.975	Q925U2 →
P70245	—	0.972	P70245 →
P64515	—	0.971	P64515 →
P64516	—	0.971	P64516 →
Q9CPU4	—	0.971	Q9CPU4 →
Q2NKS0	—	0.971	Q2NKS0 →
Q28GF8	—	0.970	Q28GF8 →
Q54GA9	—	0.970	Q54GA9 →
Q9D3B1	—	0.969	Q9D3B1 →
Q9VEG9	—	0.969	Q9VEG9 →
Q38944	—	0.968	Q38944 →
Q9JJ46	—	0.968	Q9JJ46 →
Q60490	—	0.968	Q60490 →