Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10003643 | 0.92 | BRPF1 (0.41) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10292946 | 0.91 | BRPF1 (0.42) | BRPF1SMN1; SMN2RAB9AHDAC1HDAC8 | |
| SCHEMBL10292588 | 0.91 | BRPF1 (0.45) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10292940 | 0.90 | BRPF1 (0.41) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10292513 | 0.90 | BRPF1 (0.41) | BRPF1SMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL10293264 | 0.89 | BRPF1 (0.43) | BRPF1SMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL10003262 | 0.88 | BRPF1 (0.40) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10292595 | 0.88 | RET (0.40) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10004164 | 0.88 | BRPF1 (0.47) | BRPF1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL10292511 | 0.88 | BRPF1 (0.42) | BRPF1SMN1; SMN2HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471789-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-07-04 | — | — | EP | disclosed |