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BRPF1

Peregrin · P55201 · BRPF1 on Sugi Atlas →

24,389 patent compounds predicted against BRPF1, 14,348 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1450538 SCHEMBL1450538 0.55 17/20
SCHEMBL1771879 SCHEMBL1771879 0.62 16/20
SCHEMBL762351 SCHEMBL762351 0.59 15/20
SCHEMBL422084 SCHEMBL422084 0.65 14/20
SCHEMBL1356214 SCHEMBL1356214 0.53 14/20
SCHEMBL1238373 SCHEMBL1238373 0.62 13/20
SCHEMBL1120017 SCHEMBL1120017 0.50 13/20
SCHEMBL1119743 SCHEMBL1119743 0.52 10/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1236989) 0.96 9/20
SCHEMBL763370 SCHEMBL763370 0.59 9/20
SCHEMBL1119899 SCHEMBL1119899 0.59 9/20
SCHEMBL762003 SCHEMBL762003 0.53 9/20
SCHEMBL248619 SCHEMBL248619 1.00 8/20
SCHEMBL1319712 SCHEMBL1319712 0.49 8/20
Iguratimod Iguratimod (SCHEMBL26326) 0.36 8/20
SCHEMBL1535935 SCHEMBL1535935 0.35 8/20
SCHEMBL763376 SCHEMBL763376 0.53 7/20
SCHEMBL1451027 SCHEMBL1451027 0.50 7/20
SCHEMBL340111 SCHEMBL340111 0.58 6/20
SCHEMBL534153 SCHEMBL534153 0.53 6/20

Clinical trials — most relevant to BRPF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD PHASE3COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS PHASE2COMPLETED
A Study Evaluating Megestrol Acetate Modulation in Hormone Receptor Positive Advanced Breast Cancer PHASE2UNKNOWN
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma PHASE1/PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Evaluation of the Safety and the Tolerability of a Combination of Two HIV Inducers in Patients With Undetectable Viral Load PHASE1COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) nanUNKNOWN
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Family Blood Pressure Program - GenNet Network nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Linkage Study in Familial Pulmonary Fibrosis nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Molecular Genetic Epidemiology of Endocardial Cushion Defects - SCOR in Pediatric Cardiovascular Disease nanCOMPLETED
Family Blood Pressure Program - HyperGEN nanCOMPLETED
Genetic Basis of Non Syndromic Congenital Diaphragmatic Hernia nanCOMPLETED
Chromosome 5Q Gene Variants and Asthma-Related Traits nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
Family Blood Pressure Program - SAPPHIRe Network nanCOMPLETED
Genetic Epidemiology of Asthma in Costa Rica nanCOMPLETED
Cancer in Inherited Bone Marrow Failure Syndromes nanRECRUITING
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease. nanUNKNOWN
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus nanACTIVE_NOT_RECRUITING
Genomic Dissection of a QTL Affecting the Lipid Profile nanWITHDRAWN
Genetic Basis of Abdominal Aortic Aneurysm nanCOMPLETED
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a BRPF1 binder may also engage these)

ProteinNameSimilarity
B2RRD7 — 1.000 B2RRD7 →
BRPF3 Bromodomain and PHD finger-containing protein 3 1.000 landscape →
BRD1 Bromodomain-containing protein 1 0.995 landscape →
B2KF05 — 0.995 B2KF05 →
Q7JVP4 — 0.994 Q7JVP4 →
Q80TZ9 — 0.992 Q80TZ9 →
KAT7 Histone acetyltransferase KAT7 0.992 landscape →
Q8WML3 — 0.992 Q8WML3 →
Q9P0U4 — 0.991 Q9P0U4 →
KAT8 Histone acetyltransferase KAT8 0.991 landscape →
Q5SVQ0 — 0.991 Q5SVQ0 →
A0JMK9 — 0.991 A0JMK9 →
P34442 — 0.991 P34442 →
BPTF Nucleosome-remodeling factor subunit BPTF 0.991 landscape →
Q8WUB8 — 0.991 Q8WUB8 →
Q62901 — 0.991 Q62901 →
B3M301 — 0.991 B3M301 →
Q5TKR9 — 0.991 Q5TKR9 →
Q28D84 — 0.991 Q28D84 →
Q09228 — 0.991 Q09228 →
G5EFD2 — 0.990 G5EFD2 →
Q6NRL1 — 0.990 Q6NRL1 →
P48193 — 0.990 P48193 →
Q5XI06 — 0.990 Q5XI06 →
O43150 — 0.990 O43150 →
Q6PDQ2 — 0.990 Q6PDQ2 →
Q810T5 — 0.990 Q810T5 →
B4NBP4 — 0.990 B4NBP4 →
Q6C710 — 0.990 Q6C710 →
KAT6B Histone acetyltransferase KAT6B 0.990 landscape →