Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 6/20 | 0.48 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.48 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740570 | 0.90 | NAE1 (0.44) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL2740588 | 0.89 | NAE1 (0.48) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10235267 | 0.88 | NAE1 (0.47) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10293821 | 0.88 | NAE1 (0.51) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10293816 | 0.88 | NAE1 (0.47) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10233932 | 0.86 | CA2 (0.46) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL13192031 | 0.86 | NAE1 (0.44) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10242205 | 0.86 | NAE1 (0.49) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL10236878 | 0.85 | NAE1 (0.43) | NAE1UBA3CA2SAE1UBA2 | |
| SCHEMBL191795 | 0.85 | NAE1 (0.65) | NAE1UBA3CA2SAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989206-B1 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARM INC (US) | 2012-07-04 | — | — | EP | disclosed |