Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 8/20 | 0.65 |
| ▸ | AURKA | O14965 | 6/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | PLK4 | O00444 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.48 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294830 | 0.97 | AURKB (0.64) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294969 | 0.92 | AURKA (0.67) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294687 | 0.90 | AURKA (0.77) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294961 | 0.89 | AURKB (0.65) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10295009 | 0.88 | AURKA (0.67) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10295017 | 0.88 | AURKB (0.63) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294886 | 0.87 | AURKA (0.75) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10295035 | 0.87 | AURKA (0.57) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294858 | 0.87 | AURKA (0.76) | AURKBAURKARIPK1NTRK1RET | |
| SCHEMBL10294855 | 0.87 | AURKB (0.62) | AURKBAURKARIPK1NTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
| WO-2010144359-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | ABRAXIS BIOSCIENCE, LLC (US) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CYP3A5, CYP11B2, ABCB1 | AURKB 3449/4885AURKA 3812/4885RIPK1 4814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.